Perceive: GV1001 reduces neurodegeneration and prolongs lifespan in mouse model of Alzheimer’s disease

A new analysis paper titled “GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model by diagram of anti-aging outcomes” has been printed in Rising outdated.

GV1001, which mimics the exercise of human telomerase reverse transcriptase, protects neural cells from amyloid beta (Aβ) toxicity and utterly different stressors by diagram of further-telomeric just, as infamous in our prior in vitro analysis. As per a fresh piece II clinical trial, it improves cognitive just in patients with life like to severe dementia. On the opposite hand, the underlying maintaining mechanisms dwell unclear.

On this new sight, researchers Hyun-Hee Park, Hyuk Sung Kwon, Kyu-Yong Lee, Ye Eun Kim, Jeong-Woo Son, Na-Young Choi, Myung-Hoon Han, Dong Woo Park, Sangjae Kim, and Seong-Ho Koh from Hanyang University Guri Sanatorium, Hanyang University Graduate College of Biomedical Science and Engineering and Teloid Inc. aimed to study the outcomes of GV1001 on neurodegeneration, senescence, and survival in triple transgenic Alzheimer’s disease (AD) (3xTg-AD) mice.

” […] we hypothesized that GV1001 may perchance perchance well need anti-aging outcomes and toughen neurodegeneration and senescence in vivo as a imaginable mechanism for its purposeful outcomes on AD,” the researchers write.

GV1001 (1 mg/kg) became once subcutaneously injected into mature 3xTg-AD mice thrice per week till the endpoint for sacrifice, and survival became once analyzed. Magnetic resonance imaging (MRI) and Prussian blue staining (PBS) were performed to shield in mind entry of GV1001 entrance into the brain.

Various molecular analysis were performed to study the save of GV1001 on neurodegeneration and mobile senescence in AD model mice, with a explicit focal point on BACE, amyloid beta1-42 (Aβ1-42), phosphorylated tau, quantity of dentate gyrus, β-galactosidase obvious cells, telomere length, telomerase exercise, and aging-linked proteins.

GV1001 crossed the blood-brain barrier, as confirmed by assessing the accumulate online page of ferrocenecarboxylic acid-conjugated GV1001 utilizing magnetic resonance imaging and PBS. GV1001 elevated the survival of 3xTg-AD mice. It reduced BACE and Aβ1-42 phases, neurodegeneration (i.e., reduced CA1, CA3 and dentate gyrus quantity, reduced phases of senescence-linked β-galactosidase obvious cells, and elevated telomere length and telomerase exercise), and phases of aging-linked proteins.

“We counsel that GV1001 exerts anti-aging finally ends up in 3xTg-AD mice by reducing neurodegeneration and senescence, which contributes to improved survival,” the researchers write in conclusion.

More files:
Hyun-Hee Park et al, GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model by diagram of anti-aging outcomes, Rising outdated (2024). DOI: 10.18632/aging.205489

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