The be taught, printed in The American Journal of Clinical Nutrition and funded by Linköping College, licensed the many suppression of renin and aldosterone as smartly as an impact on blood stress following intakes of glycyrrhizinic acid (GA) contained in licorice.
“We came upon licorice to be stronger than previously known, with important increases in BP, after a day-to-day intake of most efficient 100 mg of GA,” the researchers wrote. “Thus, the safe restrict of intake of this substance may per chance must be reconsidered.”
“These effects own no longer previously been demonstrated for such average portions of day-to-day intake of licorice, which is inner the vary that has been considered ‘potentially safe’ for a couple of participants,” they added.
Luca Bucchini, managing director at Hylobates Consulting, defined that outdated safety investigations into licorice own resulted in some EU Member States, honest like France and Belgium, picking to set a restrict of 100 mg for food supplements.
“Indeed, the EU assessed glycyrrhizinic acid from licorice in 2003, resulting from concerns going abet to no no longer as much as the 1990s, and came upon that below 100 mg there would be limited concerns,” he urged NutraIngredients.
“On this sense, the difficulty is no longer recent. On the opposite hand, the 100 mg restrict turned into as soon as in accordance with modelling of files, and the recent see may per chance also imply decrease limits for optimum day-to-day dose and/or warnings. Nonetheless, given the rare use of licorice in food supplements, the overall health impact is seemingly to be low, even though it may per chance be needed for hypertensive consumers to restrict consumption of licorice from any source.”
Legal guidelines on licorice
Licorice is extracted from the Glycyrrhiza species and has been historically dilapidated as a natural medication and flavouring agent. Yet, no matter previously identified health advantages, in conjunction with anti-inflammatory actions and respiratory health strengthen, consumption of the GA compound has been linked to a raised blood stress (BP). The mechanisms underlying this originate are yet to be understood.
Real intakes suggested by the European Union and the World Well being Group (WHO) are specified as as much as 100 mg GA a day. On the opposite hand, the Swedish Meals Agency has seen that the high 5% of purchasers own day-to-day intakes above this restrict.
As a result of randomised controlled trials into the results of entire candy licorice on BP are lacking and conclusions regarding the safety of ingesting 100 mg of GA for BP ranges are serene pending, primarily the most modern see sought to evaluate the results of day-to-day candy licorice intakes on BP readings and hormonal ranges.
Perceive runt print
The researchers recruited 28 wholesome contributors with a median age of 24 years. The see dilapidated a two-treatment, two-duration, two-sequence (2×2) randomized crossover possess, with contributors either starting with a licorice or a alter product. The first block consisted of a 1-week inch-in, adopted by the two-week licorice intervention, a 2-week washout, a 2-week alter duration and a additional 2-week washout duration. The 2d block reversed the sequence of 2-week sessions.
Intervention sessions involved the administration of 14.5 candy licorice pastilles day-to-day (produced by Nature Med S.r.l., Cosenza, Italy), linked to three.3 g of licorice and 100 mg of GA. At-home blood stress turned into as soon as measured day-to-day and blood samples taken after every two-week duration.
The researchers seen important increases in the systolic home BP right by contrivance of the licorice intervention duration when compared with measurements in the alter duration. BP readings were came upon to show masks increases from day 5, and persevered numerical increases were licensed except day 14.
As well to, renin and aldosterone were came upon to be suppressed right by contrivance of the licorice intervention. In contributors displaying primarily the most marked reductions of renin and aldosterone, N-terminal prohormone of brain natriuretic peptide (NT-ProBNP) turned into as soon as also came upon to be elevated right by contrivance of the intervention when compared with the alter.
“The results prove that licorice is a stronger substance than previously known and that ranges urged as ‘potentially safe’ by the WHO and the European Union is unquestionably no longer innoxious when tested in a randomized controlled surroundings with home BP recordings,” the researchers concluded.
“It is seemingly that diverse sensitive subsets, honest like of us with hypertension or renal insufficiency, would own even stronger effects of GA, hence we shuffle for additional studies on this matter. Meanwhile, we imply a more stringent warning labelling on GA containing confectionery,” they added.
Offer: The American Journal of Clinical Nutrition
doi: https://doi.org/10.1016/j.ajcnut.2024.01.011
“A low dose of day-to-day licorice intake affects renin, aldosterone, and residential blood stress in a randomized crossover trial”
Authors: Peder Af Geijerstam
